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Synaptic inhibition and γ-aminobutyric acid in the mammalian central nervous system

Advanced Search. Article Navigation. Close mobile search navigation Article Navigation. Volume Increased MBP concentrations have rarely been detected in the CSF of patients with a wide variety of neurological diseases: leukodystrophies, severe anoxia, myelopathies, and encephalopathies caused by irradiation or chemotherapy 5 17 ; the acute active state in patients with myelopathy, cerebrovascular, and neuro-Behcet diseases 6 16 ; and brain tumors We, however, found increased MBP in the CSF of five patients; one each with chronic cerebrovascular disease, amyotrophic lateral sclerosis, Parkinson disease, polyneuropathy, and meningitis.

Therefore, we used age-matched references. The study reported here was performed on MS patients to clarify the relation of clinical status to active myelin destruction by monitoring the MBP in the CSF at sequential times during the course of the disease. Longitudinal studies of individual patients showed a strict temporal relationship between the presence of MBP in the CSF and the peak of the disease.

Most patients who had increased MBP concentrations in their CSF during the acute phase of disease seemed to be in remission several months later. Antigenic material that cross-reacts with MBP, or a peptide thereof, may be present in the blood of individuals who have had recent injury to the myelin in the central nervous system. Palfreyman et al. Jacque et al. Indeed, even when the blood-brain barrier has been broken, the dilution effect caused by the larger blood volume lowers the MBP concentration below the detection limit of most assays.


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MBP is also a minor component of peripheral nervous systems. MBP therefore could be detected only rarely in the serum and at low concentrations. Several magnetic resonance imaging methods have been developed recently that may provide an objective measure of MS disease activity Skip to main content. Research Article Enzymes and Protein Markers.

Published September Mitsuhiro Ohta. Figure 1. Figure 2. Figure 3. Figure 4. Formation, structure and biochemistry of myelin. Basic neurochemistry, 3rd ed : 63 Little and Brown Boston. Radioimmunoassay of myelin basic protein in spinal fluid: an index of active demyelination. N Engl J Med ; : Whitaker JN. Myelin encephalitogenic protein fragments in cerebrospinal fluid of persons with multiple sclerosis. Neurology ; 27 : Components in multiple sclerosis cerebrospinal fluid that are detected by radioimmunoassay for myelin basic protein. Antigenic features of myelin basic protein-like material in cerebrospinal fluid.

J Immunol ; : Radioimmunoassay of myelin basic protein in cerebrospinal fluid and its clinical application to patients with neurological diseases.

Life Sci ; 27 : A diagnostic index of active demyelination: myelin basic protein in cerebrospinal fluid. Ann Neurol ; 8 : 25 There are 90 known genes that encode human neuropeptide precursors.

An Examination of the Functions, Pathways and Excitation of the Glutamate Neurotransmitter

Neuromodulators may alter the output of a physiological system by acting on the associated inputs for instance, central pattern generators. However, modeling work suggests that this alone is insufficient, [24] because the neuromuscular transformation from neural input to muscular output may be tuned for particular ranges of input.

Stern et al. Neurotransmitter systems are systems of neurons in the brain expressing certain types of neurotransmitters , and thus form distinct systems. Activation of the system causes effects in large volumes of the brain, called volume transmission. Volume transmission is the diffusion of neurotransmitters through the brain extracellular fluid released at points that may be remote from the target cells with the resulting activation of extrasynaptic receptors, and with a longer time course than for transmission at a single synapse.

Neuromodulation also refers to an emerging class of medical therapies that target the nervous system for restoration of function such as in cochlear implants , relief of pain, or control of symptoms, such as tremor seen in movement disorders like Parkinson's disease. The therapies consist primarily of targeted electrical stimulation, or infusion of medications into the cerebrospinal fluid using intrathecal drug delivery, such as baclofen for spasticity. Electrical stimulation devices include deep brain stimulation systems DBS , colloquially referred to as "brain pacemakers", spinal cord stimulators SCS and vagus nerve stimulators VNS , which are implanted using minimally invasive procedures, or transcutaneous electrical nerve stimulation devices, which are fully external, among others.

1. Introduction

From Wikipedia, the free encyclopedia. For the therapy, see Neuromodulation medicine. For other uses, see Neuromodulation disambiguation. See also: Neural pathways. July The Journal of Neuroscience. International Journal of Sports Medicine. Edinburgh: Churchill Livingstone. Descending projections of the pontomesencephalic tegmentum". Brain Res. Projections from the pontomesencephalic tegmentum to the thalamus, tectum, basal ganglia, and basal forebrain".

What does serotonin do? Medical News Today.

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Retrieved 12 April Principles of Neural Science. Retrieved 7 November In Porter, Robert S. The Merck Manual 19 ed. Whitehouse Station, N.

Merck Manuals Professional Edition. Psychiatric Times. Cleveland Clinic Journal of Medicine.

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Progress in Neurobiology. Alcohol Health and Research World. Hunter; Rezai, Ali R. Neuromodulation, Vol. Academic Press. Retrieved 6 September See Ion channel modulators. Histamine receptor agonist Histamine receptor antagonist H 1 H 2 H 3. Opioid modulator Opioid receptor agonist Opioid receptor antagonist Enkephalinase inhibitor. Cofactor see Enzyme cofactors Precursor see Amino acids. Nervous system. Sensory nerve Motor nerve Cranial nerve Spinal nerve.

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